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Meatloaf Sandwich

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Trisha SprouseBy Trisha Sprouse
Trisha Sprouse
Trisha Sprouse Food Editor

Trisha is a three-time Webby Award-winning editor/producer with a passion for creating and editing recipes and food videos that inspire home chefs to try new dishes.

Expertise: Vegetarian Cooking, Easy Entertaining, Kid-Friendly Recipes View all posts →
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Make the most of leftovers with a mouthwatering Meatloaf Sandwich.

Meatloaf Sandwich

There’s literally nothing I dread more than standing in front of the fridge in the middle of a busy week, wondering what to make for dinner. This is exactly why I love to make meatloaf—not only is it one of my family’s favorites, but I always end up with leftovers. Therefore, I know I’m guaranteed to have at least two dinners covered for the week. And without question, this delicious meatloaf sandwich is my go-to staple for leftovers.

Tender and juicy beef, gooey cheese, and crunchy sourdough come together in one satisfying bite. Plus, the sliced tomato provides just the right amount of acidity to balance the savory flavors, and the lettuce lends a nice bit of freshness. Seriously, leftovers never tasted so good.

I personally love how customizable a meatloaf sandwich is. Not only can you pick your favorite bread, cheese, and veggies, but you can even get creative with the condiments beyond just mayo. Think: BBQ Sauce, hot sauce, or even rémoulade sauce. No matter what you choose to top your meatloaf sandwich with, I can promise you it’s going to be top-tier comfort food due to its hearty nature and tie to nostalgia.

Meatloaf Sandwich

Are Meatloaf Sandwiches Healthy?

Meatloaf contains ground beef, which is high in saturated fat and cholesterol. Therefore, it’s best to enjoy it in moderation. The same can be said for this meatloaf sandwich, as it adds additional fat and calories with the cheese, mayo, bread, and butter. There are, however, ways to lighten up the dish. For instance, you can use a leaner cut of beef for the meatloaf like 90%/10%, or you could use ground turkey instead. You could also substitute egg whites instead of whole eggs to bind the meatloaf together. Furthermore, you could add grated vegetables, such as carrots or zucchini, to add more fiber and nutrients to the meatloaf. 

As for the other ingredients, this recipe calls for sourdough bread, which has a lower glycemic index than white bread. But you could swap it out with a gluten-free bread (just be sure to use gluten-free breadcrumbs in the meatloaf as well). If you are looking for a healthier substitute for mayo, you could substitute it with Greek yogurt or mashed avocado. You could even omit the cheese to lower the calorie and fat content. Embrace the creative freedom to make the meatloaf sandwich your own!

What Meatloaf Recipe Should I Use?

If you don’t have a tried-and-trusted meatloaf recipe that you love to make, this Meatloaf recipe is a classic version that’s always a crowd-pleaser. However, you may also like this Italian Meatloaf, which uses a mix of beef and pork. Or, for a lighter version, take a look at this easy Turkey Meatloaf. There’s also this Gluten-Free Meatloaf if you don’t eat gluten.

Meatloaf Sandwich

How Do I Store Leftovers?

Have leftovers from your leftovers? Simply store your meatloaf sandwiches in an airtight container in the fridge for up to 2 days. If you’d rather freeze them, first wrap them in aluminum foil and store them in a freezer-safe container in the freezer for up to 3 months. Then you can thaw them overnight and enjoy them the following day.
When reheating your meatloaf sandwich, you can cook it in a skillet over medium-low heat until the sandwich heats back up to temperature. However, if you have a panini press on hand, that would be my choice for reheating. Hot, sizzling meatloaf sandwich coming right up! And if you’d like to eat your meatloaf sandwich cold, that’s a tasty option, too.

Meatloaf Sandwich

Serving Suggestions

Since a meatloaf sandwich is somewhat similar to a burger, it pairs well with all the burger’s classic side dishes: French Fries, Homemade Potato Chips, or Onion Rings. For something lighter, you could also pair it with a Green Salad.

Love a hearty casserole-style side dish instead? I recommend this Cheesy Corn Casserole, Green Bean Casserole, or Mashed Potato Casserole. Whew, my mouth is watering!

Meatloaf Sandwich

Recipe

Meatloaf Sandwich

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Serves: 4
Meatloaf Sandwich
Prep: 5 minutes minutes
Cook: 15 minutes minutes
0 minutes minutes
Total: 20 minutes minutes

Ingredients

  • 4 slices leftover meatloaf
  • 8 slices sourdough bread
  • 2 tablespoons mayonnaise
  • 2 tablespoons butter softened
  • 4 slices cheddar cheese
  • Sliced tomato
  • Lettuce
  • Salt and pepper to taste

Instructions

  • Heat a large nonstick skillet over medium heat. Place the meatloaf slices in the skillet and cook until warmed through and lightly browned, about 3 minutes per side.
    Meatloaf Sandwich
  • Spread one side of each slice of bread with mayonnaise and the other side with butter. Place 4 slices of bread, buttered-side down, in the skillet.
    Meatloaf Sandwich
  • Top each slice of bread with a slice of cheese, a slice of warmed meatloaf, tomato slices, and lettuce. Season with salt and pepper to taste.
    Meatloaf Sandwich
  • Place the remaining slices of bread on top, buttered-side up. Grill the sandwiches until the bread is toasted and the cheese is melted, about 2-4 minutes per side.
    Meatloaf Sandwich
  • Remove from the skillet and let cool for a few minutes before serving.

Nutrition Info:

Calories: 452kcal (23%) Carbohydrates: 67g (22%) Protein: 14g (28%) Fat: 15g (23%) Saturated Fat: 5g (31%) Sodium: 867mg (38%) Fiber: 3g (13%) Sugar: 6g (7%)

Nutrition Disclaimer

Nutrition information are estimates only and may vary based on the specific brands, ingredients, and portion sizes you use. This data is provided for informational purposes only.

Author: Trisha Sprouse
Course:Dinner
Cuisine:American
Share your creationsTag @foodfaithfit and hashtag it #foodfaithfitness so I can see what you made!
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Fresh young woman with long brown hair and natural makeup smiling confidently indoors, representing healthy eating, wellness, and fitness lifestyle on Food Faith Fitness website.

About Trisha SprouseVegetarian Cooking, Easy Entertaining, Kid-Friendly Recipes

Trisha is a three-time Webby Award-winning editor/producer with a passion for creating and editing recipes and food videos that inspire home chefs to try new dishes.

Reader Interactions

Paola Westbeek

✓Reviewed by Paola WestbeekGastronomy & Fine Wines

Published: Aug 12, 2024 | Updated: Oct 17, 2025

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