Preheat your oven to 450 degrees F. Line a baking sheet with foil and coat with non-stick cooking spray.
In a large resealable bag, combine panko breadcrumbs, garlic powder, onion powder, smoked paprika, sea salt, and black pepper. Seal and shake to mix.
Crack the egg into a shallow dish and beat lightly. Dip each chicken tender into the egg, then drop into the bag with the panko mixture. Seal and shake to coat the chicken evenly.
Place the coated chicken tenders on the prepared baking sheet in a single layer. Spray lightly the top of each tender with cooking spray.