In a small bowl, combine the ranch seasoning, red pepper flakes, garlic powder, and onion powder.
Melt the butter in a large skillet over medium heat.
Add the oyster crackers to the skillet, stirring to coat with the melted butter. Cook for 4-5 minutes until lightly toasted.
Take the skillet off the heat and sprinkle the seasoning mix over the crackers, tossing to coat thoroughly.